Inhibition of Herpes Simplex Virus 1 Reproduction with Hydrophobized Antisense Oligonucleotides
Identifieur interne : 004428 ( Main/Exploration ); précédent : 004427; suivant : 004429Inhibition of Herpes Simplex Virus 1 Reproduction with Hydrophobized Antisense Oligonucleotides
Auteurs : S. V. Vinogradov [Russie] ; Y. Suzdaltseva [Russie] ; V. Y. Alakhov [Russie] ; A. V. Kabanov [Russie]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 1994.
Abstract
Abstract: Antisense oligonucleotides were modified by their ends with hydrophobic substituents which permitted enhancing their activity. The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the splicing site 983-994 of early mRNA-5 of the virus and 19-mer complementary to the site of mRNA that encodes the virus DNA-polymerase. These oligonucleotides were modified by 5′-ends with n-undecyl or cholesteryl moieties and by 3′-ends with acridine or 1,7-heptanediol. In comparison with the unnmodified oligonucleotides the hydrophobized ones were significantly more active and inhibited HSV-1 infection at micromolar concentrations.
Url:
DOI: 10.1006/bbrc.1994.2275
Affiliations:
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Kabanov</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow Inst Biotechnol Inc, Moscow 119899, Russia and Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119899</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Biochemical and Biophysical Research Communications</title><title level="j" type="abbrev">YBBRC</title><idno type="ISSN">0006-291X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">203</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="959">959</biblScope><biblScope unit="page" to="966">966</biblScope></imprint><idno type="ISSN">0006-291X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-291X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Antisense oligonucleotides were modified by their ends with hydrophobic substituents which permitted enhancing their activity. The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the splicing site 983-994 of early mRNA-5 of the virus and 19-mer complementary to the site of mRNA that encodes the virus DNA-polymerase. These oligonucleotides were modified by 5′-ends with n-undecyl or cholesteryl moieties and by 3′-ends with acridine or 1,7-heptanediol. In comparison with the unnmodified oligonucleotides the hydrophobized ones were significantly more active and inhibited HSV-1 infection at micromolar concentrations.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Vinogradov, S V" sort="Vinogradov, S V" uniqKey="Vinogradov S" first="S. V." last="Vinogradov">S. V. 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